About¶

What is surface morphometrics?¶

Surface morphometrics is the quantitative analysis of surface geometry and topology in biological membranes and cellular structures. Starting from voxel segmentations of cryo-electron tomography (cryo-ET) data, the pipeline generates surface meshes and computes morphological measurements.

Morphometrics Workflow

Core components¶

Component	What it does
Mesh Generation	Converts voxel segmentations into surface meshes using screened Poisson reconstruction
PyCurv	Computes curvature measurements using a vector voting framework
Distance & Orientation	Measures distances and relative orientations between surfaces
3D Visualization	Interactive rendering of surfaces with property colormaps

References¶

Original pipeline: surface_morphometrics by the Grotjahn Lab
Paper: Barad et al. (2023) — Quantitative analysis of membrane ultrastructure using cryo-ET surface morphometrics